DEF8

Across TCGA patient cohorts, DEF8 protein abundance is significantly associated with the RNA expression of many other genes, with 2,253 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible DEF8-associated genes across cancer lineages are MCOLN2, ROPN1L-AS1, and PARP11-AS1. Each is linked with DEF8 in more than 2 cancer types. Because this analysis shows association rather than direction, both DEF8-to-partner and partner-to-DEF8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DEF8 versus MCOLN2 in HNSC, with a Pearson correlation of -0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEF8→partner) and Y-score (partner→DEF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MCOLN2 →	-1.088	-0.439	.007	.007	3	2
HNSC	ROPN1L-AS1 →	-0.539	-0.444	.004	.002	3	2
HNSC	PARP11-AS1 →	-0.739	-0.385	<.001	.003	3	2
UCEC	FAM83D →	-1.021	-0.337	<.001	.002	3	2
UCEC	ASF1B →	-0.834	-0.379	.005	<.001	3	2
UCEC	ALDH1A2 →	+1.203	+0.437	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,253 associations by consensus.

DEF8 vs MCOLN2 — HNSC

Explore this scatter interactively →