DEF8

Across TCGA patient cohorts, DEF8 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEF8-associated genes across cancer lineages are TFRC, ATM, and C-Raf. Each is linked with DEF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEF8-to-partner and partner-to-DEF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by DEF8-low versus DEF8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEF8→partner) and Y-score (partner→DEF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.606	+2.415	.004	.003	3	2
UCEC	ATM →	-0.863	-3.087	<.001	<.001	3	2
UCEC	C-Raf →	+0.126	+2.459	.028	.019	3	2
UCEC	14-3-3_beta →	-0.100	-2.973	.013	.035	3	1
UCEC	EGFR_pY1068 →	-0.271	-2.415	.007	.003	3	1
UCEC	eIF4E →	+0.193	+1.906	.022	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

TFRC by DEF8 expression — UCEC

Explore this box plot interactively →