DEF8

Across TCGA cell cohorts, DEF8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,556 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DEF8-associated GO terms across cancer lineages are Regulation of establishment of protein localization to telomere, Spindle localization, and Peptidyl-proline modification. Each is linked with DEF8 in more than 13 cancer types. Because this analysis shows association rather than direction, both DEF8-to-partner and partner-to-DEF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of establishment of protein localization to telomere grouped by DEF8-low versus DEF8-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DEF8→partner) and Y-score (partner→DEF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of establishment of protein localization to telomere →	+0.103	+0.810	<.001	.001	3	14
BREAST	Spindle localization →	+0.056	+0.710	.003	<.001	3	12
PANCREAS	Peptidyl-proline modification →	+0.128	+0.845	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Peptidyl-proline hydroxylation →	+0.209	+0.967	<.001	<.001	3	12
STOMACH	Regulation of establishment of protein localization to chromosome →	+0.104	+0.788	.006	.001	2	12
UPPER_AERODIGESTIVE_TRACT	Dorsal root ganglion development →	+0.201	+0.767	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,556 associations by consensus.

Regulation of establishment of protein localization to telomere by DEF8 expression — OVARY

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