DEF8

Across TCGA cell cohorts, DEF8 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DEF8-associated genes across cancer lineages are APOL5, BTBD16, and NPFFR1. Each is linked with DEF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEF8-to-partner and partner-to-DEF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOL5 grouped by DEF8-low versus DEF8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEF8→partner) and Y-score (partner→DEF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	APOL5 →	+0.010	+3.475	.007	.006	3	1
BLOOD_Leukemia	BTBD16 →	+0.081	+3.959	<.001	.005	3	1
BLOOD_Leukemia	NPFFR1 →	+0.014	+4.359	<.001	<.001	3	1
BLOOD_Leukemia	CLDN8 →	+0.011	+4.556	<.001	<.001	3	1
BLOOD_Leukemia	ELOA3DP →	+0.097	+4.007	.008	.002	3	1
BLOOD_Leukemia	SMIM23 →	+0.015	+4.569	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

APOL5 by DEF8 expression — BLOOD_Leukemia

Explore this box plot interactively →