DEF6

Across TCGA pan-cancer cohorts, DEF6 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DEF6 data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DEF6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DEF6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and COAD are the cancer types where DEF6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.855	0.305	.008	20	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	7	view →
COAD	DFS	Tertile	All	0.927	1.000	.048	6	view →
LUAD	DFS	Quartile	All	0.871	0.608	.007	5	view →
OV	DFS	Tertile	All	0.884	0.536	.048	4	view →
UCEC	OS	Tertile	II,III,IV	1.000	0.612	.041	4	view →
LSCC	DFS	Median	III,IV	0.934	0.635	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DEF6–HNSC (DFS)

Open the HNSC breakdown →