DEF6

Across TCGA patient cohorts, DEF6 mutation is significantly associated with the RNA expression of many other genes, with 1,424 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEF6-associated genes across cancer lineages are RN7SKP286, RN7SL870P, and NPBWR2. Each is linked with DEF6 in more than 2 cancer types. Because this analysis shows association rather than direction, both DEF6-to-partner and partner-to-DEF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP286 grouped by DEF6-low versus DEF6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEF6→partner) and Y-score (partner→DEF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SKP286 →	+0.051	+4.810	<.001	.002	3	3
LUSC	RN7SL870P →	+0.107	+4.606	<.001	.006	3	3
LUAD	NPBWR2 →	+0.290	+3.690	<.001	.009	3	2
CESC	RNU1-17P →	+0.307	+4.103	<.001	.002	3	2
BRCA	BTF3P15 →	+0.140	+6.064	.004	.002	3	2
UCEC	CDCA2 →	+0.808	+2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,424 associations by consensus.

RN7SKP286 by DEF6 expression — SKCM

Explore this box plot interactively →