DEF6

Across TCGA patient cohorts, DEF6 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEF6-associated genes across cancer lineages are 4E-BP1, FoxM1, and EGFR_pY1068. Each is linked with DEF6 in more than 2 cancer types. Because this analysis shows association rather than direction, both DEF6-to-partner and partner-to-DEF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by DEF6-low versus DEF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEF6→partner) and Y-score (partner→DEF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.252	+3.029	.033	.018	3	3
UCEC	FoxM1 →	+0.223	+2.115	.048	.019	3	2
UCEC	EGFR_pY1068 →	-0.259	-2.807	.018	.003	3	1
UCEC	EGFR_pY1173 →	+0.087	+2.142	.012	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.152	-2.794	.039	.003	3	1
UCEC	JNK2 →	+0.284	+2.115	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

4E-BP1 by DEF6 expression — UCEC

Explore this box plot interactively →