DEF6

Across TCGA cell cohorts, DEF6 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DEF6-associated genes across cancer lineages are ITIH6, ELMOD1, and NUDT10. Each is linked with DEF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEF6-to-partner and partner-to-DEF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITIH6 grouped by DEF6-low versus DEF6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEF6→partner) and Y-score (partner→DEF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ITIH6 →	+0.020	+4.169	<.001	<.001	3	1
BLOOD_Leukemia	ELMOD1 →	+0.154	+3.557	.002	.005	3	1
BLOOD_Leukemia	NUDT10 →	+1.078	+3.532	.001	.005	3	1
BLOOD_Leukemia	BHLHE23 →	+0.998	+3.691	.003	.005	3	1
BLOOD_Leukemia	NGF →	+0.288	+3.594	<.001	.007	3	1
BLOOD_Leukemia	BTBD16 →	+0.070	+3.959	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ITIH6 by DEF6 expression — BLOOD_Leukemia

Explore this box plot interactively →