DEDD2

Across TCGA patient cohorts, DEDD2 mutation is significantly associated with the RNA expression of many other genes, with 361 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEDD2-associated genes across cancer lineages are S100A11P8, CASKP1, and AK4P6. Each is linked with DEDD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEDD2-to-partner and partner-to-DEDD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S100A11P8 grouped by DEDD2-low versus DEDD2-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEDD2→partner) and Y-score (partner→DEDD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	S100A11P8 →	+0.144	+7.939	<.001	.008	3	2
SKCM	CASKP1 →	+0.072	+5.224	.001	.007	3	1
SKCM	AK4P6 →	+0.110	+4.979	<.001	.009	3	1
HNSC	RNU6-492P →	+0.478	+7.954	<.001	.008	3	1
HNSC	RNU6-169P →	+0.273	+7.954	<.001	.008	3	1
HNSC	RNU4-26P →	+0.268	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 361 associations by consensus.

S100A11P8 by DEDD2 expression — PRAD

Explore this box plot interactively →