DEDD2

Across TCGA patient cohorts, DEDD2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEDD2-associated genes across cancer lineages are Smac, TIGAR, and eIF4E. Each is linked with DEDD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEDD2-to-partner and partner-to-DEDD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smac grouped by DEDD2-low versus DEDD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEDD2→partner) and Y-score (partner→DEDD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Smac →	+0.315	+3.000	.037	.037	3	1
UCEC	TIGAR →	+0.176	+3.026	.046	.019	3	1
UCEC	eIF4E →	+0.264	+3.000	.030	.037	1	1
UCEC	14-3-3_zeta →	+0.336	+3.026	.004	.019	1	1
UCEC	4E-BP1 →	+0.470	+3.000	.002	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Smac by DEDD2 expression — UCEC

Explore this box plot interactively →