DEDD

Across TCGA pan-cancer cohorts, DEDD Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DEDD data layer compared with 26 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher DEDD Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DEDD expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

THYM, SCLC, and UCEC are the cancer types where DEDD Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
SCLC	OS	Median	All	0.219	0.706	.011	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
STAD	OS	Median	All	0.167	0.567	.030	3	view →
BLCA	DFS	Median	All	0.865	0.327	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DEDD–THYM (OS)

Open the THYM breakdown →