DEDD

Across TCGA pan-cancer cohorts, DEDD mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated DEDD data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DEDD mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DEDD expression acts as an unfavorable survival marker.

UCEC and LSCC are the cancer types where DEDD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.767	0.947	.027	4	view →
LSCC	DFS	Quartile	All	0.661	1.000	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

DEDD–UCEC (DFS)

Open the UCEC breakdown →