DEDD

Across TCGA patient cohorts, DEDD mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEDD-associated genes across cancer lineages are JNK_pT183_Y185, Ku80, and p62 Lck ligand. Each is linked with DEDD in more than 1 cancer types. Because this analysis shows association rather than direction, both DEDD-to-partner and partner-to-DEDD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by DEDD-low versus DEDD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEDD→partner) and Y-score (partner→DEDD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.219	-2.446	.007	.020	3	1
UCEC	Ku80 →	+0.350	+3.331	.002	.005	3	1
UCEC	p62 Lck ligand →	+0.435	+3.009	.005	.019	3	1
UCEC	PKC-delta_pS664 →	-0.116	-3.169	.045	.018	3	1
UCEC	STAT3_pY705 →	-0.590	-3.321	<.001	.009	3	1
UCEC	VHL →	-1.141	-3.321	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

JNK_pT183_Y185 by DEDD expression — UCEC

Explore this box plot interactively →