DEDD

Across TCGA cell cohorts, DEDD RNA expression is significantly associated with the go_rna of many other GO terms, with 3,504 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DEDD-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Positive regulation of double-strand break repair via homologous recombination, and Chromosome condensation. Each is linked with DEDD in more than 12 cancer types. Because this analysis shows association rather than direction, both DEDD-to-partner and partner-to-DEDD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by DEDD-low versus DEDD-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DEDD→partner) and Y-score (partner→DEDD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Negative regulation of gene expression, epigenetic →	+0.057	+0.666	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair via homologous recombination →	+0.086	+0.881	<.001	<.001	3	13
BONE	Chromosome condensation →	+0.148	+0.684	.006	.008	3	13
BREAST	Positive regulation of mitotic cytokinesis →	+0.183	+0.751	<.001	.002	3	12
LARGE_INTESTINE	Regulation of protein sumoylation →	+0.115	+0.739	.001	<.001	3	12
BONE	Establishment of mitotic spindle localization →	+0.126	+0.832	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,504 associations by consensus.

Negative regulation of gene expression, epigenetic by DEDD expression — BLOOD_Lymphoma

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