DEDD

Across TCGA cell cohorts, DEDD mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DEDD-associated genes across cancer lineages are GJD2 and SLC15A5. Each is linked with DEDD in more than 1 cancer types. Because this analysis shows association rather than direction, both DEDD-to-partner and partner-to-DEDD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJD2 grouped by DEDD-low versus DEDD-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEDD→partner) and Y-score (partner→DEDD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GJD2 →	+0.005	+5.022	<.001	.002	3	1
LARGE_INTESTINE	SLC15A5 →	+0.017	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

GJD2 by DEDD expression — LARGE_INTESTINE

Explore this box plot interactively →