DEDD

Across TCGA cell cohorts, DEDD mutation is significantly associated with the mutation status of many other genes, with 1,899 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DEDD-associated genes across cancer lineages are PGM2, CSDE1, and MEIS2. Each is linked with DEDD in more than 2 cancer types. Because this analysis shows association rather than direction, both DEDD-to-partner and partner-to-DEDD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGM2 grouped by DEDD-low versus DEDD-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEDD→partner) and Y-score (partner→DEDD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PGM2 →	+4.584	+4.584	.007	.007	1	3
BLOOD_Lymphoma	CSDE1 →	+5.584	+5.014	.003	.003	1	3
BLOOD_Lymphoma	MEIS2 →	+5.169	+5.832	<.001	<.001	1	3
BLOOD_Lymphoma	NODAL →	+5.584	+5.014	.003	.003	1	3
BLOOD_Lymphoma	CACNG2 →	+5.584	+5.014	.003	.003	1	3
BLOOD_Lymphoma	OXSR1 →	+5.584	+5.014	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,899 associations by consensus.

PGM2 by DEDD expression — BLOOD_Lymphoma

Explore this box plot interactively →