DECR2

Across TCGA patient cohorts, DECR2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DECR2-associated genes across cancer lineages are Myosin-IIa_pS1943, Myosin-IIa, and SLC1A5. Each is linked with DECR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DECR2-to-partner and partner-to-DECR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa_pS1943 grouped by DECR2-low versus DECR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DECR2→partner) and Y-score (partner→DECR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	+0.242	+1.887	.011	.031	3	1
UCEC	Myosin-IIa →	+0.198	+1.881	.021	.031	3	1
UCEC	SLC1A5 →	-0.491	-2.999	.013	.034	3	1
UCEC	p62 Lck ligand →	+0.382	+2.584	.011	.011	2	1
UCEC	p38-MAPK →	+0.175	+2.584	.022	.011	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Myosin-IIa_pS1943 by DECR2 expression — UCEC

Explore this box plot interactively →