DECR2

Across TCGA cell cohorts, DECR2 mutation is significantly associated with the mutation status of many other genes, with 4,051 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DECR2-associated genes across cancer lineages are HSF1, USP4, and ZNF423. Each is linked with DECR2 in more than 3 cancer types. Because this analysis shows association rather than direction, both DECR2-to-partner and partner-to-DECR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSF1 grouped by DECR2-low versus DECR2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DECR2→partner) and Y-score (partner→DECR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HSF1 →	+6.044	+6.044	.001	.001	1	4
CNS	USP4 →	+6.044	+6.044	.001	.001	1	4
BLOOD_Leukemia	ZNF423 →	+3.115	+4.080	.001	.001	1	4
BLOOD_Leukemia	DMXL2 →	+2.197	+3.280	.007	.007	1	4
STOMACH	TMEM63C →	+4.807	+4.807	.008	.008	1	4
CNS	LATS2 →	+6.044	+6.044	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,051 associations by consensus.

HSF1 by DECR2 expression — CNS

Explore this box plot interactively →