DECR1

Across TCGA pan-cancer cohorts, DECR1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated DECR1 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher DECR1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DECR1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and BLCA show a favorable association.

UVM, LUAD, and ESCA are the cancer types where DECR1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.384	0.788	<.001	136	view →
LUAD	DFS	Quartile	II,III,IV	0.418	0.684	<.001	86	view →
ESCA	DFS	Tertile	All	0.258	0.506	.002	43	view →
KIRP	OS	Tertile	II,III,IV	0.894	0.563	.001	38	view →
HNSC	OS	Quartile	All	0.646	0.885	.008	29	view →
BLCA	OS	Quartile	II,III,IV	0.685	0.531	.010	24	view →
CESC	DFS	Tertile	All	0.876	0.759	.017	20	view →
READ	OS	Quartile	II,III,IV	1.000	0.363	.011	20	view →
LAML	DFS	Tertile	All	0.472	0.687	.009	20	view →
BRCA	OS	Median	III,IV	0.314	0.711	.004	16	view →
MESO	OS	Median	All	0.728	0.294	.009	15	view →
KIRC	DFS	Quartile	All	0.751	0.503	<.001	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

DECR1–UVM (DFS)

Open the UVM breakdown →