DEAF1

Across TCGA patient cohorts, DEAF1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEAF1-associated genes across cancer lineages are ATM, ERK2, and FoxM1. Each is linked with DEAF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DEAF1-to-partner and partner-to-DEAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DEAF1-low versus DEAF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEAF1→partner) and Y-score (partner→DEAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.392	-1.415	.021	.046	3	3
UCEC	ERK2 →	+0.172	+1.700	.017	.042	3	2
UCEC	FoxM1 →	+0.302	+2.169	.001	.003	3	2
UCEC	MEK1 →	+0.411	+2.662	.002	<.001	3	2
UCEC	PCNA →	+0.263	+2.169	.001	.003	3	2
UCEC	14-3-3_beta →	-0.106	-2.558	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

ATM by DEAF1 expression — UCEC

Explore this box plot interactively →