DEAF1

Across TCGA cell cohorts, DEAF1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DEAF1-associated genes across cancer lineages are MMD2, KRT35, and SYCN. Each is linked with DEAF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEAF1-to-partner and partner-to-DEAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMD2 grouped by DEAF1-low versus DEAF1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEAF1→partner) and Y-score (partner→DEAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MMD2 →	+0.063	+5.087	<.001	.004	3	1
URINARY_TRACT	KRT35 →	+0.040	+5.087	<.001	.004	3	1
BLOOD_Leukemia	SYCN →	+0.047	+5.539	<.001	.003	3	1
BLOOD_Leukemia	USP17L3 →	+0.012	+4.922	.009	.009	3	1
LARGE_INTESTINE	CRYBB1 →	+0.724	+2.878	<.001	.009	3	1
LARGE_INTESTINE	GUCY2F →	+0.007	+3.103	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

MMD2 by DEAF1 expression — URINARY_TRACT

Explore this box plot interactively →