DDX60L

Across TCGA pan-cancer cohorts, DDX60L mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DDX60L data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DDX60L mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DDX60L expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where DDX60L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.296	0.463	.010	11	view →
LUAD	OS	Median	All	0.656	0.851	.015	9	view →
HNSC	OS	Median	IV	0.817	0.602	.020	5	view →
GBM	OS	Median	All	0.297	0.546	.035	4	view →
CCRCC	DFS	Median	All	1.000	0.849	.015	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DDX60L–PDAC (DFS)

Open the PDAC breakdown →