DDX60L

Across TCGA patient cohorts, DDX60L mutation is significantly associated with the RNA expression of many other genes, with 4,247 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX60L-associated genes across cancer lineages are PKMYT1, ECHS1, and TIPIN. Each is linked with DDX60L in more than 3 cancer types. Because this analysis shows association rather than direction, both DDX60L-to-partner and partner-to-DDX60L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKMYT1 grouped by DDX60L-low versus DDX60L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX60L→partner) and Y-score (partner→DDX60L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKMYT1 →	+0.766	+1.917	<.001	<.001	3	4
LUSC	ECHS1 →	+0.394	+3.011	<.001	<.001	3	4
UCEC	TIPIN →	+0.497	+2.436	<.001	<.001	3	4
LUAD	PBK →	+1.214	+3.348	.002	.005	3	4
UCEC	UQCRC1 →	+0.345	+1.752	.001	<.001	3	4
UCEC	OIP5 →	+0.877	+2.743	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,247 associations by consensus.

PKMYT1 by DDX60L expression — UCEC

Explore this box plot interactively →