DDX60L

Across TCGA patient cohorts, DDX60L mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX60L-associated genes across cancer lineages are Caspase-7-cleavedD198, p70-S6K, and ASNS. Each is linked with DDX60L in more than 3 cancer types. Because this analysis shows association rather than direction, both DDX60L-to-partner and partner-to-DDX60L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DDX60L-low versus DDX60L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX60L→partner) and Y-score (partner→DDX60L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.658	+2.267	<.001	<.001	3	4
UCEC	p70-S6K →	+0.130	+1.380	.031	.009	3	3
LUSC	ASNS →	+0.434	+3.179	.049	.010	1	4
UCEC	eIF4E →	+0.221	+2.115	<.001	<.001	3	2
UCEC	GAPDH →	+0.434	+2.700	.010	.005	3	2
UCEC	Notch1 →	+0.193	+1.836	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

Caspase-7-cleavedD198 by DDX60L expression — UCEC

Explore this box plot interactively →