DDX59

Across TCGA pan-cancer cohorts, DDX59 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DDX59 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DDX59 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DDX59 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where DDX59 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.284	0.947	.008	34	view →
CCRCC	DFS	Median	IV	0.781	0.220	.017	7	view →
PDAC	OS	Tertile	All	0.761	0.948	.010	6	view →
LUAD	DFS	Median	III,IV	1.000	0.498	.017	3	view →
LSCC	DFS	Quartile	II,III,IV	0.804	0.482	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DDX59–HNSC (DFS)

Open the HNSC breakdown →