DDX59

Across TCGA patient cohorts, DDX59 protein abundance is significantly associated with the RNA expression of many other genes, with 11,759 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DDX59-associated genes across cancer lineages are PRPF3, POLR3C, and RAB3GAP2. Each is linked with DDX59 in more than 7 cancer types. Because this analysis shows association rather than direction, both DDX59-to-partner and partner-to-DDX59 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DDX59 versus PRPF3 in HNSC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX59→partner) and Y-score (partner→DDX59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PRPF3 →	+0.708	+0.230	<.001	.001	3	8
UCEC	POLR3C →	+0.577	+0.310	<.001	<.001	3	8
UCEC	RAB3GAP2 →	+0.783	+0.384	<.001	<.001	3	7
UCEC	RRNAD1 →	+0.726	+0.251	<.001	<.001	3	7
HNSC	EIF2D →	+0.737	+0.331	<.001	<.001	3	7
UCEC	HNRNPU →	+0.522	+0.287	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,759 associations by consensus.

DDX59 vs PRPF3 — HNSC

Explore this scatter interactively →