DDX59

Across TCGA patient cohorts, DDX59 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX59-associated genes across cancer lineages are ATM, 4E-BP1, and EGFR_pY1068. Each is linked with DDX59 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX59-to-partner and partner-to-DDX59 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DDX59-low versus DDX59-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX59→partner) and Y-score (partner→DDX59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.565	-1.986	.001	.029	3	2
UCEC	4E-BP1 →	+0.388	+3.614	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.210	-1.906	.037	.016	3	1
UCEC	eIF4E →	+0.232	+4.169	.006	<.001	3	1
UCEC	JNK2 →	+0.254	+1.906	.001	.016	3	1
UCEC	Ku80 →	+0.252	+1.498	.008	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ATM by DDX59 expression — UCEC

Explore this box plot interactively →