DDX59

Across TCGA cell cohorts, DDX59 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,214 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DDX59-associated GO terms across cancer lineages are Establishment of protein localization to endoplasmic reticulum membrane, Regulation of endoplasmic reticulum tubular network organization, and Positive regulation of ATP-dependent activity. Each is linked with DDX59 in more than 11 cancer types. Because this analysis shows association rather than direction, both DDX59-to-partner and partner-to-DDX59 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of protein localization to endoplasmic reticulum membrane grouped by DDX59-low versus DDX59-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX59→partner) and Y-score (partner→DDX59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Establishment of protein localization to endoplasmic reticulum membrane →	+0.104	+0.590	<.001	.008	2	12
STOMACH	Regulation of endoplasmic reticulum tubular network organization →	+0.140	+0.849	<.001	<.001	3	7
STOMACH	Positive regulation of ATP-dependent activity →	+0.099	+0.795	.002	<.001	3	7
LUNG_NSCLC_LUSC	Vesicle targeting, rough ER to cis-Golgi →	+0.117	+0.668	<.001	.002	3	7
LUNG_SCLC	Positive regulation of chromatin organization →	+0.145	+0.579	<.001	<.001	3	7
SKIN	Protein deglycosylation →	+0.070	+0.455	.004	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,214 associations by consensus.

Establishment of protein localization to endoplasmic reticulum membrane by DDX59 expression — STOMACH

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