DDX59

Across TCGA cell cohorts, DDX59 mutation is significantly associated with the RNA expression of many other genes, with 1,471 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDX59-associated genes across cancer lineages are OR10W1, GRK3, and CCDC134. Each is linked with DDX59 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX59-to-partner and partner-to-DDX59 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by DDX59-low versus DDX59-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX59→partner) and Y-score (partner→DDX59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR10W1 →	+0.013	+5.781	<.001	.001	3	2
LARGE_INTESTINE	GRK3 →	+0.733	+2.115	<.001	.004	3	2
LARGE_INTESTINE	CCDC134 →	+0.639	+3.453	.002	.001	3	2
LARGE_INTESTINE	SAMM50 →	+0.514	+2.179	<.001	.001	3	2
LARGE_INTESTINE	RELCH →	+0.868	+3.043	<.001	<.001	3	2
LARGE_INTESTINE	SEC24B →	+0.575	+1.956	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,471 associations by consensus.

OR10W1 by DDX59 expression — BREAST

Explore this box plot interactively →