DDX58

Across TCGA pan-cancer cohorts, DDX58 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DDX58 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher DDX58 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DDX58 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

COAD, HNSC, and LUAD are the cancer types where DDX58 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.911	1.000	.012	72	view →
HNSC	DFS	Quartile	III,IV	1.000	0.349	.036	18	view →
LUAD	OS	Median	All	0.973	0.911	.023	13	view →
PDAC	OS	Tertile	III,IV	0.850	0.484	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DDX58–COAD (DFS)

Open the COAD breakdown →