DDX58

Across TCGA patient cohorts, DDX58 mutation is significantly associated with the RNA expression of many other genes, with 3,449 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX58-associated genes across cancer lineages are SHLD3, MIR3133, and FCER1G. Each is linked with DDX58 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX58-to-partner and partner-to-DDX58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHLD3 grouped by DDX58-low versus DDX58-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX58→partner) and Y-score (partner→DDX58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SHLD3 →	+0.488	+3.839	<.001	<.001	3	3
LUSC	MIR3133 →	+0.538	+2.947	<.001	.007	3	3
UCEC	FCER1G →	+0.772	+2.392	<.001	<.001	3	3
UCEC	PKN3 →	+0.933	+3.534	<.001	<.001	3	3
UCEC	GLOD4 →	+0.516	+2.403	<.001	<.001	3	3
UCEC	SPATA5L1 →	+0.503	+3.939	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,449 associations by consensus.

SHLD3 by DDX58 expression — UCEC

Explore this box plot interactively →