DDX58

Across TCGA cell cohorts, DDX58 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,840 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DDX58-associated GO terms across cancer lineages are Negative regulation of viral genome replication, Positive regulation of canonical NF-kappaB signal transduction, and Positive regulation of interleukin-4-mediated signaling pathway. Each is linked with DDX58 in more than 16 cancer types. Because this analysis shows association rather than direction, both DDX58-to-partner and partner-to-DDX58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of viral genome replication grouped by DDX58-low versus DDX58-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX58→partner) and Y-score (partner→DDX58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Negative regulation of viral genome replication →	+0.208	+1.840	<.001	<.001	3	16
BLOOD_Lymphoma	Positive regulation of canonical NF-kappaB signal transduction →	+0.062	+1.105	<.001	<.001	3	16
STOMACH	Positive regulation of interleukin-4-mediated signaling pathway →	+0.732	+1.147	<.001	.006	3	15
KIDNEY	Regulation of viral process →	+0.115	+1.638	.003	.004	3	15
KIDNEY	Defense response to virus →	+0.102	+1.775	.001	.004	3	15
UPPER_AERODIGESTIVE_TRACT	Regulation of viral life cycle →	+0.127	+1.664	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,840 associations by consensus.

Negative regulation of viral genome replication by DDX58 expression — CNS

Explore this box plot interactively →