DDX58

Across TCGA cell cohorts, DDX58 mutation is significantly associated with the RNA expression of many other genes, with 61 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDX58-associated genes across cancer lineages are LCE1C, SLC5A8, and OR10A6. Each is linked with DDX58 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX58-to-partner and partner-to-DDX58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE1C grouped by DDX58-low versus DDX58-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX58→partner) and Y-score (partner→DDX58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LCE1C →	+0.432	+4.922	.002	.009	3	1
BLOOD_Leukemia	SLC5A8 →	+0.182	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR10A6 →	+0.044	+5.201	<.001	.006	3	1
BLOOD_Leukemia	CFHR2 →	+0.395	+5.539	<.001	.003	3	1
SKIN	SCRT2 →	+0.006	+4.095	<.001	.009	3	1
LARGE_INTESTINE	RPF1 →	+0.672	+3.087	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

LCE1C by DDX58 expression — BLOOD_Leukemia

Explore this box plot interactively →