DDX52

Across TCGA patient cohorts, DDX52 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX52-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and A-Raf_pS299. Each is linked with DDX52 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX52-to-partner and partner-to-DDX52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by DDX52-low versus DDX52-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX52→partner) and Y-score (partner→DDX52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.094	-2.295	.028	.033	3	2
UCEC	EGFR_pY1068 →	-0.224	-2.459	.035	.019	3	1
UCEC	A-Raf_pS299 →	-0.155	-3.459	.002	.005	3	1
UCEC	ERK2 →	+0.256	+3.584	.001	.002	3	1
UCEC	ACC_pS79 →	+0.301	+1.700	.040	.044	3	1
UCEC	JNK_pT183_Y185 →	-0.209	-3.459	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

14-3-3_beta by DDX52 expression — UCEC

Explore this box plot interactively →