Across TCGA pan-cancer cohorts, DDX51 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated DDX51 data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher DDX51 RNA is associated with better overall survival. In most high-consensus cancer types, elevated DDX51 expression acts as an unfavorable survival marker, although some lineages such as SCLC and BRCA show a favorable association.

SCLC, LIHC, and ACC are the cancer types where DDX51 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	0.634	0.320	<.001	98	view →
LIHC	DFS	Median	All	0.464	0.615	<.001	61	view →
ACC	DFS	Quartile	II,III,IV	0.248	0.784	.002	52	view →
LUSC	DFS	Median	III,IV	0.407	0.883	.006	41	view →
BRCA	OS	Median	III,IV	0.952	0.848	<.001	39	view →
KICH	DFS	Median	All	0.671	1.000	.004	31	view →
THYM	DFS	Median	All	0.929	0.613	.002	29	view →
PRAD	DFS	Tertile	All	0.903	0.963	.003	22	view →
MESO	DFS	Quartile	IV	0.211	0.752	.010	13	view →
SKCM	DFS	Median	III,IV	0.173	0.418	.011	12	view →
UVM	OS	Median	III,IV	0.296	1.000	.005	12	view →
BLCA	DFS	Quartile	IV	0.542	0.346	.019	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

Exploration

Same gene, other analysis: DDX51 tumor-vs-normal RNA expression · all DDX51 data types