DDX50

Across TCGA pan-cancer cohorts, DDX50 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DDX50 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DDX50 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DDX50 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LUAD, GBM, and PDAC are the cancer types where DDX50 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	1.000	0.541	.011	18	view →
GBM	DFS	Tertile	All	0.387	0.228	.007	15	view →
PDAC	DFS	Median	III,IV	0.191	0.518	.013	12	view →
CCRCC	OS	Median	All	0.892	1.000	.004	11	view →
LSCC	DFS	Quartile	II,III,IV	0.832	0.551	.048	2	view →
HNSC	DFS	Median	IV	1.000	0.924	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DDX50–LUAD (OS)

Open the LUAD breakdown →