DDX50

Across TCGA patient cohorts, DDX50 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX50-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and FOXO3a_pS318_S321. Each is linked with DDX50 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX50-to-partner and partner-to-DDX50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DDX50-low versus DDX50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX50→partner) and Y-score (partner→DDX50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.532	+1.874	.008	.049	3	2
UCEC	EGFR_pY1068 →	-0.263	-1.807	.002	.004	3	1
UCEC	FOXO3a_pS318_S321 →	-0.101	-1.405	.017	.043	3	1
UCEC	IGFBP2 →	-0.564	-1.874	.010	.049	3	1
UCEC	JNK_pT183_Y185 →	-0.164	-2.700	.004	.006	3	1
UCEC	JNK2 →	+0.260	+3.643	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Caspase-7-cleavedD198 by DDX50 expression — UCEC

Explore this box plot interactively →