DDX50

Across TCGA cell cohorts, DDX50 mutation is significantly associated with the RNA expression of many other genes, with 725 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDX50-associated genes across cancer lineages are HCRTR2, LRIT1, and GPR101. Each is linked with DDX50 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX50-to-partner and partner-to-DDX50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HCRTR2 grouped by DDX50-low versus DDX50-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX50→partner) and Y-score (partner→DDX50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HCRTR2 →	+0.010	+3.551	.004	.009	3	1
BLOOD_Leukemia	LRIT1 →	+0.032	+4.269	<.001	.002	3	1
BLOOD_Leukemia	GPR101 →	+0.102	+3.551	<.001	.009	3	1
BLOOD_Leukemia	MBD3L3 →	+0.018	+3.874	.008	.005	3	1
BLOOD_Leukemia	PRR30 →	+0.021	+4.269	<.001	.002	3	1
BLOOD_Leukemia	TMEM215 →	+0.051	+4.234	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 725 associations by consensus.

HCRTR2 by DDX50 expression — BLOOD_Leukemia

Explore this box plot interactively →