DDX49

Across TCGA pan-cancer cohorts, DDX49 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DDX49 data layer compared with 29 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DDX49 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DDX49 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

PDAC, CCRCC, and GBM are the cancer types where DDX49 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.389	0.654	.006	14	view →
CCRCC	DFS	Median	III,IV	0.556	0.856	.008	13	view →
GBM	OS	Tertile	All	0.670	0.474	.015	8	view →
HNSC	DFS	Tertile	IV	0.464	0.762	.009	5	view →
LUAD	OS	Quartile	II,III,IV	0.299	0.911	.015	4	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.886	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DDX49–PDAC (OS)

Open the PDAC breakdown →