DDX49

Across TCGA patient cohorts, DDX49 mutation is significantly associated with the RNA expression of many other genes, with 1,546 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX49-associated genes across cancer lineages are RNU6-991P, NUP210P1, and FGFR3P1. Each is linked with DDX49 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX49-to-partner and partner-to-DDX49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-991P grouped by DDX49-low versus DDX49-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX49→partner) and Y-score (partner→DDX49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNU6-991P →	+0.381	+5.033	<.001	.009	3	2
LUAD	NUP210P1 →	+0.069	+5.410	<.001	.005	3	2
LUAD	FGFR3P1 →	+0.091	+5.984	<.001	.002	3	2
COAD	NPM1P17 →	+0.122	+3.789	<.001	.004	3	2
SKCM	MIR4650-2 →	+0.566	+6.328	<.001	.001	3	2
HNSC	RNA5SP433 →	+0.467	+5.736	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,546 associations by consensus.

RNU6-991P by DDX49 expression — LIHC

Explore this box plot interactively →