DDX43

Across TCGA pan-cancer cohorts, DDX43 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DDX43 data layer compared with 26 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher DDX43 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DDX43 expression acts as an unfavorable survival marker, although some lineages such as OV and BLCA show a favorable association.

SKCM, OV, and UCEC are the cancer types where DDX43 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.661	0.876	.001	11	view →
OV	OS	Median	III,IV	1.000	0.308	.036	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUSC	OS	Median	III,IV	0.011	0.664	<.001	6	view →
BLCA	DFS	Median	II,III,IV	1.000	0.608	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DDX43–SKCM (OS)

Open the SKCM breakdown →