DDX43

Across TCGA cell cohorts, DDX43 mutation is significantly associated with the RNA expression of many other genes, with 576 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDX43-associated genes across cancer lineages are IQCF5, ANKRD54, and DEPDC5. Each is linked with DDX43 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX43-to-partner and partner-to-DDX43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by DDX43-low versus DDX43-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX43→partner) and Y-score (partner→DDX43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCF5 →	+0.124	+5.201	<.001	.006	3	2
LARGE_INTESTINE	ANKRD54 →	+0.540	+3.299	.002	.004	3	1
LARGE_INTESTINE	DEPDC5 →	+0.757	+3.212	<.001	.006	3	1
LARGE_INTESTINE	POLDIP3 →	+0.609	+3.192	.003	.007	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.658	+3.212	.001	.006	3	1
LARGE_INTESTINE	ZBED4 →	+0.680	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 576 associations by consensus.

IQCF5 by DDX43 expression — BLOOD_Leukemia

Explore this box plot interactively →