Across TCGA cell cohorts, DDX42 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDX42-associated genes across cancer lineages are KRT28, WFDC13, and DBX2. Each is linked with DDX42 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX42-to-partner and partner-to-DDX42 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX42→partner) and Y-score (partner→DDX42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KRT28 →	+0.006	+4.544	<.001	.003	3	2
BLOOD_Leukemia	WFDC13 →	+0.035	+4.922	<.001	.009	3	1
BREAST	DBX2 →	+0.016	+5.781	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.017	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	GYPB →	+0.103	+4.544	<.001	.003	3	1
LARGE_INTESTINE	CD244 →	+0.182	+3.215	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

DDX42 survival (RNA) · tumor vs normal (RNA) · all DDX42 data types