DDX41

Across TCGA pan-cancer cohorts, DDX41 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DDX41 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher DDX41 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DDX41 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

STAD, COAD, and BRCA are the cancer types where DDX41 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.457	0.740	.014	12	view →
COAD	OS	Median	All	0.001	0.871	<.001	12	view →
BRCA	DFS	Median	All	0.814	0.950	.034	2	view →
UCEC	DFS	Median	All	0.948	0.628	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DDX41–STAD (OS)

Open the STAD breakdown →