DDX41

Across TCGA pan-cancer cohorts, DDX41 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DDX41 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DDX41 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DDX41 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where DDX41 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.739	0.979	<.001	107	view →
PDAC	DFS	Tertile	II,III,IV	0.280	0.585	.002	19	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	10	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.888	.008	4	view →
LSCC	DFS	Median	II,III,IV	0.878	0.686	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DDX41–CCRCC (OS)

Open the CCRCC breakdown →