DDX41

Across TCGA patient cohorts, DDX41 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,900 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DDX41-associated proteins across cancer lineages are NPM1, NPM1_T199, and TTC1. Each is linked with DDX41 in more than 5 cancer types. Because this analysis shows association rather than direction, both DDX41-to-partner and partner-to-DDX41 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DDX41 versus NPM1 in LSCC, with a Pearson correlation of 0.58.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX41→partner) and Y-score (partner→DDX41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NPM1 →	+0.344	+0.364	<.001	<.001	3	6
LUAD	NPM1_T199 →	+1.410	+0.346	.001	<.001	3	5
OV	TTC1 →	+0.465	+0.665	<.001	<.001	3	5
CCRCC	RARS1 →	+0.203	+0.463	<.001	<.001	3	5
LSCC	PLCL2_S1113 →	-0.614	-0.309	<.001	<.001	3	5
GBM	MCM2 →	+0.659	+0.397	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,900 associations by consensus.

DDX41 vs NPM1 — LSCC

Explore this scatter interactively →