DDX41

Across TCGA patient cohorts, DDX41 mutation is significantly associated with the RNA expression of many other genes, with 1,316 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX41-associated genes across cancer lineages are RNU6-909P, SYPL1P1, and ACOD1. Each is linked with DDX41 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX41-to-partner and partner-to-DDX41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-909P grouped by DDX41-low versus DDX41-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX41→partner) and Y-score (partner→DDX41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-909P →	+0.401	+4.888	.001	<.001	3	3
UCEC	SYPL1P1 →	+0.105	+2.579	<.001	.001	3	3
UCEC	ACOD1 →	+0.125	+2.175	.002	.004	3	3
UCEC	MED31 →	+0.456	+3.202	.001	<.001	3	3
UCEC	ZBTB17 →	+0.362	+2.748	.006	.003	3	3
UCEC	MIR6803 →	+0.137	+4.308	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,316 associations by consensus.

RNU6-909P by DDX41 expression — BRCA

Explore this box plot interactively →