DDX41

Across TCGA patient cohorts, DDX41 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX41-associated genes across cancer lineages are Cyclin-B1, FoxM1, and S6_pS240_S244. Each is linked with DDX41 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX41-to-partner and partner-to-DDX41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by DDX41-low versus DDX41-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX41→partner) and Y-score (partner→DDX41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.746	+2.700	.003	.006	3	3
SKCM	FoxM1 →	+0.208	+2.321	.041	.035	3	2
UCEC	S6_pS240_S244 →	+0.549	+2.000	.002	.032	3	2
UCEC	eIF4E →	+0.213	+3.807	.025	<.001	3	2
UCEC	A-Raf_pS299 →	-0.211	-3.169	<.001	.019	3	2
UCEC	INPP4B →	-0.346	-2.459	.017	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Cyclin-B1 by DDX41 expression — UCEC

Explore this box plot interactively →