DDX41

Across TCGA cell cohorts, DDX41 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,156 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible DDX41-associated GO terms across cancer lineages are Positive regulation of mitotic cell cycle, DNA-templated transcription initiation, and Cell cycle checkpoint signaling. Each is linked with DDX41 in more than 10 cancer types. Because this analysis shows association rather than direction, both DDX41-to-partner and partner-to-DDX41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitotic cell cycle grouped by DDX41-low versus DDX41-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX41→partner) and Y-score (partner→DDX41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of mitotic cell cycle →	+0.081	+0.995	.006	.004	3	11
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.060	+0.654	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Cell cycle checkpoint signaling →	+0.079	+0.909	<.001	<.001	3	10
BLOOD_Myeloma	Regulation of DNA-templated transcription initiation →	+0.053	+0.875	<.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Protein localization to chromosome →	+0.089	+0.719	<.001	.003	3	9
BONE	Thymidine biosynthetic process →	+0.184	+0.668	.003	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,156 associations by consensus.

Positive regulation of mitotic cell cycle by DDX41 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →