DDX41

Across TCGA cell cohorts, DDX41 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DDX41-associated genes across cancer lineages are ITGAD, SCGB3A2, and IFIT1B. Each is linked with DDX41 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX41-to-partner and partner-to-DDX41 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAD grouped by DDX41-low versus DDX41-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX41→partner) and Y-score (partner→DDX41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ITGAD →	+0.011	+3.510	<.001	.003	3	1
LARGE_INTESTINE	SCGB3A2 →	+0.282	+3.510	.003	.003	3	1
LARGE_INTESTINE	IFIT1B →	+0.027	+3.823	.003	.006	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.010	+4.022	<.001	.006	3	1
BLOOD_Leukemia	SLC5A4 →	+0.361	+4.471	<.001	.001	3	1
BLOOD_Leukemia	MYL10 →	+0.018	+4.569	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ITGAD by DDX41 expression — LARGE_INTESTINE

Explore this box plot interactively →